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KMID : 0378019880310060119
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New Medical Journal
1988 Volume.31 No. 6 p.119 ~ p.129
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A Clinical Study for the Captopril Effects on Hypertensive Patients
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ïËÙ¥ûà/Jeong, Myung Ho
ãéâåÔÆ/åÄã¯òÒ/ÚÓßÔòÒ/ÑÑã¯Î°/ðáæÅε/ÚÓñ£õð/Shin, Soon Chul/Yong, Seung Jin/Park, Sang Jin/Kim, Seung Guan/Jo, Jeong Gwan/Park, Jong Chun
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Abstract
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Captopril, an angiotensin converting enzyme inhibitor, was administrated in 30 hypertensive patients
(mild 8, moderate 12, severe 10 cases) for-12 weeks or longer in order to observe the hypotensive eff- ts.
Changes in quality of life, side effects, electrocardiogram and left ventricular mass index (LVMI) by T -
guided M-mode echocardiography were also evaluated before and after captopril.
1. After 12 weeks¢¥ treatment with 25 to 150 mg of captopril alone, blood pressures were lowered marke ? ly in 16(53%), moderately in 5(17%) and mildly in 2(7%), while the addition of 25 mg hydrochlorthiaz de to captopril in the patients who showed no satisfactory responses the blood pressure were lowe ed. markedly in 21(70%), moderately in 6(20%) and mildly 3(10%) out of 30 patients studied. The aver. ! e of blood pressures of the 30 subjects were systolic 180.7¡¾20.7 mmHg (M¡¾ SD) and diastolic 113.2 ¡¾ 1..5 before treatment, which were lowered to 148¡¾15.8 and 92.5¡¾8.0 mmHg respectively afte 12 wee¢¥ (P<0.005).
2. Heart rates were not changed with captopil and/or hydrochlorthiazide.
3.. Quality of life improved markedly in 5(17%) and slightly in 12(40%) out of 30 subjects.
4. Complete blood cell count, urinalysis and serum enzymes followed revealed no significant changes. 5. By electrocardiographic follow-up studies 1 out of 13 subjects with LVH, 1 out of 4 LAH, 1 out of 2 ST-T changes were revealed to improve to normal.
6. In 25 out of 30 cases left ventricular mass indices (LVMI) were above 125 g/m2 before treatment, among which 15 cases were followed with satisfactorily good quality of the echocardiographic recordings and the LVMI was reduced from 169.6¡¾40.7 to 141.7¡¾40.9 g/m2 (P50.01)
7. Undesirable side effects were dry cough 3, skin.rash 2, dysgeusia 1 and renal dysfunction 1.
8. Considering the blood pressure lowering effects, life quality changes and side effects together the catopril was considered very useful in 8(27%) and useful in 16(53%) out of 30 subjects.
Above results suggest that captoril can be prescribed as an effective initial single agents or with i combinations with thiazide for the treatment of hypertension of various severities with acceptably low sid effects.
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